赵瑞瑞，博士，讲师，青岛大学青年卓越。1993年生，山西绛县人，2023年6月毕业于福州大学生物化工专业，同年8月加入青岛大学材料科学与工程学院-生化工程研究院。主要聚焦于肿瘤防治相关的纳米药物制剂的研究，通过设计与合成智能纳米药物递送系统，用于光热/光动力癌症治疗以及癌症免疫治疗。成果主要发表在Biomaterials、Acta Biomaterialia、Journal of Colloid and Interface Science等国外期刊。主持山东省自然科学基金一项。

研究方向：

1、基于天然产物的抗肿瘤纳米药物递送系统；

2、金属有机配位自组装纳米药物；

3、肿瘤的光动力治疗、免疫治疗的基础研究。

联系方式：

Email: zhaoruirui1@qdu.edu.cn

代表性论文：

1.Ru-Gui Liu^#, Rui-Rui Zhao^#*, Zi-Wei Yu, Feng-Juan Liu, Chun-Zhao Liu, Xiao Wu, Metal-organic coordinated self-assembled nanomedicine for enhanced cuproptosis-mediated chemo-photo-chemodynamic synergistic therapy of non-small cell lung cancer, Chemical Engineering Journal, 2025, 509, 161305.

2. Yao-Lin Wu, Rui-Rui Zhao*, Xiao Wu, Chun-Lei Liu, Chun-Zhao Liu*, Carrier-free nanodrug based on small molecule drug and sonosensitizer for enhanced the ferroptosis-driven multimodal synergistic therapy of prostate cancer, European Journal of Pharmaceutics And Biopharmaceutics, 2025, 208: 114656.

3. Rui-Rui Zhao^#, Ju-Hong Wu^#, Ling-Wu Tong, Jin-Yu Li, Yu-Sheng Lu, Jing-Wei Shao*. Multifunctional metal-coordinated Co-assembled carrier-free nanoplatform based on dual-drugs for ferroptosis-mediated cocktail therapy of hepatocellular carcinoma growth and metastasis. Journal of Colloid and Interface Science, 2024, 660: 257-276.

4. Rui-Rui Zhao, Yi-Fan Fang, Zi-Xuan Chen, Jing-Qing Le, Long-Guang Jiang Jing-Wei Shao*. Self-assembled Amphiphile-based Nanoparticles for the Inhibition of Hepatocellular Carcinoma Metastasis via ICAM-1 Mediated Cell Adhesion. Acta Biomaterialia, 2020, 111: 373-385.

5. Ruirui Zhao, Guirong Zheng, Lulu Fan, Zhichun Shen, Kai Jiang, Yan Guo, Jing-Wei Shao*. Carrier-free nanodrug by co-assembly of chemotherapeutic agent and photosensitizer for cancer imaging and chemo-photo combination therapy. Acta Biomaterialia, 2018, 70:197-210.

6. Ruirui Zhao^#, Tao Li^#, Guirong Zheng, Kai Jiang, Lulu Fan, Jingwei Shao*. Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex. Biomaterials. 2017,143:1-16.

7. Shijing Yu^#, Ruirui Zhao^#, Bingchen Zhang, Chunmei Lai, Linyan Li, Jiangwen Shen, Xiarong Tan, Jingwei Shao*. Research progress and application of the CRISPR/Cas9 gene-editing technology based on hepatocellular carcinoma. Asian Journal of Pharmaceutical Sciences, 2023, 18(4):100828.